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Position Details
Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences
Location: University of Birmingham, Edgbaston, Birmingham UK
Full time starting salary is normally in the range £34,980 to £44,263 with potential progression once in post to £46,974
Grade: 7
Full Time, Fixed Term contract up to July 2027
Closing date: 14th May 2024
Background
To create and contribute to the creation of knowledge by investigating genesis of fusion genes in paediatric cancer using NPM-ALK as an exemplar.
Role summary
A University of Birmingham funded research fellow position is available to work in the lab of Professor Jon Frampton in collaboration with Professor Amos Burke in the Institute for Cancer and Genomic Sciences at the University of Birmingham and with Professor Suzanne Turner (University of Cambridge).
Fusion genes and proteins are an important feature of childhood cancer but their genesis and function are poorly understood. Extending the work of the Turner lab in Cambridge, in long-standing collaboration with Amos Burke, this work will generate new understanding of fusion genes using NPM-ALK as a paradigm that has been extensively studied in the Turner lab. The Frampton lab has extensive experience and expertise in stem cell biology.
The finding of a variety of pre-malignant fusion genes in cord blood or in cytokine-stimulated CD34+ cells remains unexplained and no mechanism for their generation has been elaborated. Understanding of the processes involved in the generation of fusion genes will open potential avenues for new therapeutic approaches in childhood cancer.
All applicants should be proficient with basic tissue culture and molecular biology techniques and flow cytometry. Prior experience with metabolic analysis approaches is desirable but not required. Bioinformatics experience would be advantageous. Applicants should be able to demonstrate prior research success; for example, through publications/pre-prints, presentations at conferences and relevant academic prizes/travel awards.
Main Duties
The responsibilities may include some but not all of the responsibilities outlined below.
Person Specification
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